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Catecholamine Response to the Clinical Use of Alpha Adrenergic Receptor Blocking Agents
Author(s) -
Risbo A.,
JessenM.D. K.,
Hagelsten J. O.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01908.x
Subject(s) - medicine , endocrinology , catecholamine , norepinephrine , adrenergic receptor , reflex , vasoconstriction , phenoxybenzamine , receptor , thermoregulation , adrenergic , thermogenesis , sympathetic nervous system , blood pressure , heart rate , anesthesia , adipose tissue , dopamine
Treatment with alpha adrenergic receptor blocking agents has been used clinically for many years to obviate peripheral vasoconstriction in patients suffering from circulatory or thermoregulatory distress. Various reports indicating that administration of these agents may be followed by an increased plasma concentration of catecholamines, and subsequently an increased oxygen demand, led to 29 investigations on humans who we replaced in a horizontal position in a thermoneutral environment and given 25 mg chlorpromazine intravenously, dissolved in 500 cc low molecular weight dextran. Blood pressure and heart rate remained unchanged during the infusions and significant changes in plasma noradrenaline (average fall: 4.42 nmol·1 ‐1 , range: ‐31.9‐ + 5.1) and in plasma adrenaline (average fall: 1.06 nmol·1 ‐1 , range: ‐ 16.3‐ + 5.11) were observed ( P <0.01). The results indicate that as long as any baro‐reflex activation of the sympathetic nervous system and acceleration of the nonshivering thermogenesis is avoided, the recommended treatment with alpha adrenergic receptor blocking agents can be performed without any increase in plasma concentration of catecholamines.