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Interactions of Anaesthesia and High Pre‐operative Doses of β‐Receptor Antagonists *
Author(s) -
PrysRoberts C.
Publication year - 1982
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1982.tb01888.x
Subject(s) - medicine , propranolol , anesthesia , chronotropic , inotrope , blockade , hemodynamics , lidocaine , blood pressure , cardiology , heart rate , receptor
Haemodynamic responses to anaesthesia and surgery were observed in 13 patients with severe renovascular hypertension treated with high doses of β‐receptor antagonists (equivalent to 10–37 mg/kg/day of propranolol) and 24 patients receiving moderate doses of β‐receptor antagonists (equivalent to 120–480 mg propranolol per day). Chronotropic and inotropic responses to the noxious stimuli of laryngoscopy or surgical stimulation were effectively suppressed by β‐receptor blockade thus increasing arterial pressure due to these stimuli or aortic cross‐clamping which indicated a purely resistive load for the left ventricle. In no patient was evidence found that myocardial performance, and its effect on left ventricular ejection, was seriously compromised.