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Effects of Prenalterol on Renal Function in Normal Man
Author(s) -
Järnberg P.O.,
Westman L.
Publication year - 1982
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1982.tb01824.x
Subject(s) - medicine , plasma renin activity , excretion , endocrinology , free water clearance , blood pressure , fractional excretion of sodium , renal function , renal blood flow , renal physiology , heart rate , sodium , hemodynamics , kidney , renin–angiotensin system , chemistry , organic chemistry
The effects of prenalterol infusion, 0.5 μg/kg/min, on renal function were studied in 10 male volunteers. Systolic blood pressure increased by 22 mmHg( P <0.01) and diastolic pressure decreased by 11 mmHg ( P <0.01). Heart rate increased by 11 beats/min ( P <0.01). Plasma catecholamine levels and plasma renin activity were not altered. Renal haemodynamics were unchanged. Urine flow rate and fractional free water excretion decreased by 29% and 45%, respectively ( P <0.01). Fractional sodium excretion increased by 19% ( P <0.01) and fractional potassium excretion fell by 33% ( P <0.05).