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Reversal of Procaine Conduction Blockade by Adenine Nucleotides in Vivo and in vitro
Author(s) -
Kraynack B. J.,
Gintautas J.
Publication year - 1982
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1982.tb01777.x
Subject(s) - procaine , adenine nucleotide , adenosine , nucleotide , adenosine monophosphate , adenosine triphosphate , in vivo , medicine , in vitro , anesthesia , pharmacology , biochemistry , endocrinology , chemistry , biology , microbiology and biotechnology , gene
The effect of the adenine nucleotides on procaine‐induced conduction block in rats was investigated in vivo and in vitro. Both adenine and cyclic nucleotides significantly shortened the duration of sciatic nerve Mucks in rats without affecting the frequency, degree of block or time of onset. Adenosine 5′ triphosphate (ATP) and N ‐6 , O 2 dibutyryl 3′:5′‐monophosphate (db‐cyclic AMP) were most effective. In isolated sciatic nerve preparations. the adenine nucleotides (ATP, adenosine 5′diphosphate (ADP), adenosine 5′monophosphate (AMP)) rapidly reversed procaine‐induced depression of the action potential. These results suggest that local anesthetic effects may be mediated through interference with the physiological functions of the nucleotides.