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The Role of Halothane and Fentanyl in the Production of Balanced Anaesthesia
Author(s) -
Tammisto T.,
Aromaa U.
Publication year - 1982
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1982.tb01759.x
Subject(s) - halothane , medicine , fentanyl , anesthesia , endotracheal tube , ventilation (architecture) , respiration , intubation , anatomy , mechanical engineering , engineering
The aim of the study was to quantitate the degree of respiratory depression when tolerance of superficial nociception and of an endotracheal tube was achieved by supplementing N 2 O + O 2 anaesthesia either with halothane alone or with halothane in combination with fentanyl. Eighty‐four patients, matched into sewn groups, were studied after induction of anaesthesia with thiopental (4 mg/kg) and suxamethonium (3 mg/kg) using the following supplementation: 0.8, 0.6, 0.4% halothane alone or 0.4, 0.2, 0% halothane with 0.5‐2 μg/kg fentanyl. After 10 min administration of the anaesthetic mixture using manual intermittent positive pressure ventilation (IPPV) (end‐tidal CO 2 c. 5.5%), IPPV was discontinued and spontaneous respiration allowed to return. When the end‐tidal Co 2 had stabilized, samples for blood gas analysis were taken and superfirial antinociception was tested by pinching an inguinal skin fold. Supplementation of an N 2 O + O 2 mixture with 0.8% halothane without fentanyl or with 0.4% halothane with 0.5 μg/kg fentanyl seemed to come closest to the optimum in producing tolerance of an endotracheal tube and of superficial nociception (in about 85% of cases) with an increase in PCO 2 to only 7 kPa.