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Comparison of Intra‐ and Extracellular Buffering of Clinically Used Buffer Substances: Tris and Bicarbonate
Author(s) -
Rothe K. F.,
Diedler J.
Publication year - 1982
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1982.tb01752.x
Subject(s) - bicarbonate , tris , medicine , acidosis , metabolic acidosis , extracellular , extracellular fluid , acid–base reaction , base excess , acid–base imbalance , chromatography , biochemistry , chemistry , organic chemistry
A large and important group of acid‐base disturbances are the metabolic acidosrs. In grneral. every type of nietabolir acidosis can be treated with infusion of base when the underlying cause of the disturbances is removed. In our medical centers, the use of tris and bicarbonate is common. For a long time they were competitive agents and until now it was not possible to decide by available clinical methods which of these substances was more suitable for correction of metabolic acidosis. The intracellular pH of the whole rat (mean Icf‐pH) was determined from the distribution of 14 C labelled DMO (5,5‐dimethyl‐2,4‐oxazolidinedione) and monitored for 6 h following intravenous application of tris or sodiumbicarbonate in a dose of 10 mmol per kq body mass. Arterial plasma pH and PCO 2 were also measured. To determine and compare the effectiveness of the two buffer substances, intra‐and extracellular bicarbonate were calculated from the Henderson‐Hasselbalch equation. It was found that the buffering following bicarbonate infusion is more effective in both body compartments. Sodiumbicarbonate should be preferred in daily practice.