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Cerebral Blood Flow and Oxygen Uptake in Endotoxic Shock. An Experimental Study in Dogs
Author(s) -
EkströmJodai B.,
Häggendai E.,
LarssonM.D. L. E.
Publication year - 1982
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1982.tb01746.x
Subject(s) - cerebral blood flow , medicine , anesthesia , blood pressure , hemodynamics , shock (circulatory) , arterial blood , blood flow , oxygen tension , oxygen , chemistry , organic chemistry
Cerebral blood flow (CBF), cerebral oxygen uptake (CMRo 2 ) and central haemodynamics in anaesthetized dogs with controlled ventilation were studied at intervals for 2 h following an intravenous injection of E. coli endotoxin, 1.0–1.5 mg/kg. CBF showed a 30% decrease within 15 min after the endotoxin administration, while the arterial blood pressure was still not markedly depressed. Autoregulation to arterial blood pressure changes was maintained during endotoxinaemia and the cerebrovascular reaction to changes in arterial carbon dioxide tension (Paco 2 ) depressed. Normocapnic animals (PacO 2 ≥ 4.0 kPa) showed an increase in CMRO 2 of over 40%, that was obvious 1 h after the administration of endotoxin. The intracranial pressure was decreased within 5 min of the administration of endotoxin irrespective of the prevailing arterial blood pressure. Thereafter, it was raised above the control level. Two hours after endotoxin increased protein concentrations in cerebrospinal fluid were seen, results compatible with blood‐brain barrier damage and penetration of other substances; e.g. monoamines released during endotoxinaemia could thus be expected to have a direct influence on both cerebral blood flow and metabolism.