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Droperidol (Dehydrobenzperido®): Postoperative Anti‐Emetic Effect when Given Intravenously to Gynaecological Patients
Author(s) -
Mortensen P. T.
Publication year - 1982
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1982.tb01724.x
Subject(s) - droperidol , medicine , anesthesia , sedation , vomiting , nausea , general anaesthesia , postoperative nausea and vomiting
In a double‐blind investigation, comprising 300 gynaecological patients, the prophylactic use ol droperidol i.v. at the start of the anaesthesia produced a significant reduction in the frequency of nausea and vomiting postoperatively in the tirst 24 h from 34.4% to 10.3% (P=0.0001). There was no significant dilrercnce between the effect of droperidol 2.5 mg and 5 mg (P=0.45). Increased postoperative sedation was the only side‐cftect of any importance observed; however, this did not result in any increased period of observation in the recovery room, and the majority of patients considered it advantageous. Droperidol is recommended as a prophylactic anti‐emetic for selected groups of patients, given as 2.5 mg i.v. at the start of the anaesthesia.