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Enflurane Improves the Oxygen Supply /Demand Balance in the Acutely Ischaemic Canine Myocardium
Author(s) -
Smith G.,
Evans D. H.,
Ashek M. J.,
Bentley S.
Publication year - 1982
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1982.tb01723.x
Subject(s) - medicine , enflurane , cardiology , ischemia , artery , blood supply , anesthesia , blood flow , surgery , isoflurane
Acute myocardial ischaemia was produced in six dogs by ligation of the anterior descending branch of the left main coronary artery. Enflurane 1.5% inspired produced a significantly smaller reduction in blood flow in the ischaemic than in the non‐ischaemic area in myocardium in the presence of a 46% reduction in mean arterial pressure. The improvement in oxygen availability/consumption ratio in the ischaemic in Comparison with non‐ischaemic areas was attributed to a 16% reduction in heart rate.