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Local Discomfort and Thrombophlebitis Following Intravenous Injection of Diazepam
Author(s) -
Selander D.,
Curelaru I.,
Stekansson T.
Publication year - 1981
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1981.tb01696.x
Subject(s) - thrombophlebitis , medicine , diazepam , anesthesia , sedation , incidence (geometry) , intravenous use , ethanol , surgery , thrombosis , organic chemistry , chemistry , physics , optics
Diazepam is frequently used for pre‐ and peroperalive sedation. However, at i.v. injection local pain and thrombophlebitis are not uncommon, probably due to tissue irritancy of the various organic solvents necessary to keep diazepam in aqueous solution. In this study the incidence of local adverse effects following i.v. injection of Diazemulsr̀, a new lipid emulsion formulation, was compared with that of Apozepam, a glycoferol‐waler solution. We found that the latter preparation caused local pain and thrombophlebitis as often as reported with propyleneglycol‐phenylcarbinol‐ethanol preparations (Stesolidr̀, Valiumr̀) and in a statistically higher incidence than the lipid emulsion form, which therefore seems more suitable for intravenous use.