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Myocardial Oxygen Consumption and Coronary Haemodynamics during Fentanyl‐Droperidol‐Nitrous Oxide Anaesthesia in Patients with Ischaemic Heart Disease
Author(s) -
Reiz S.,
Bålfors E.,
Häggmark S.,
Nath S.,
Rydvall A.,
Truedsson H.
Publication year - 1981
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1981.tb01653.x
Subject(s) - medicine , coronary sinus , coronary perfusion pressure , vascular resistance , anesthesia , cardiology , hemodynamics , heart rate , rate pressure product , blood pressure , droperidol , fentanyl , resuscitation , cardiopulmonary resuscitation
Eight patients with stable ischaemic heart disease were investigated to determine the effects of fentanyl (15 μg/kg) ‐ droperidol (150 μg/kg) ‐ nitrous oxide (75%) anaesthesia, without concomitant fluid challenge, on myocardial oxygen consumption and lactate uptake, and central and coronary haemodynamics. Anaesthesia induced reductions in mean arterial pressure (— 35%, P<0.01), systemic vascular resistance (— 30%, P<0.01), left ventricular stroke work index (—50%, P<0.01) and total body oxygen consumption (— 23%, P<0.01), with no changes in heart rate, cardiac output or mean pulmonary arteriolar occlusion pressure. Mixed venous oxygen content increased (P< 0.05). Systemic vasodilatation, circulatory adaptation to an overall lower metabolic rate, and clinically negligible cardiodepression are the likely mechanisms behind the central haemodynamic response to this form of anaesthesia. Coronary sinus blood flow (measured by the continuous thermodilution technique) decreased (P<0.01) in parallel with the decrease in coronary perfusion pressure. Thus coronary vascular resistance remained unchanged. As expected from the haemodynamic findings, myocardial oxygen consumption decreased (—37%, P<0.01). Coronary sinus oxygen content and myocardial oxygen extraction did not change, nor was myocardial lactate uptake affected. No ST‐T‐segment depressions or dysrhythmias were recorded. These observations indicate that myocardial oxygenation was adequate in spite of the reduction in coronary perfusion pressure. There was poor correlation between changes in myocardial oxygen consumption and rate pressure product (R=0.455) or triple product (R=0.375).