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Disopyramide Anticholinergic Action
Author(s) -
Byrne A. J.,
Healy T. E. J.,
Mahmoodi V.,
Poole T. R.
Publication year - 1981
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1981.tb01650.x
Subject(s) - disopyramide , carbachol , liter , medicine , anticholinergic , anesthesia , endocrinology , receptor
The effect of disopyramide on cholinergic transmission has been studied using the frog isolated abdominis rectus preparation and the guinea pig isolated vas deferens hypogastric nerve preparation. Disopyramide (2 × 10 ‐5 mol litre ‐1 ) reduced the response of the abdominis rectus to carbachol (1.36 × 10 ‐6 — 4.8 × 10 ‐5 mol litre ‐1 ). Furthermore, disopyramide (1 × 10 ‐6 —3 × 10 ‐4 mol litre ‐1 ) produced a concentration‐dependent reduction in the response to carbachol (5.46 × 10 ‐6 mol litre). The response to potassium chloride (3.34 × 10 mol litre ‐1 ) was unaltered by disopyramide (1 × 10 —3 × 10 ‐4 mol litre ‐1 ). Disopyramide produced a dose‐related ganglionic blockade at concentrations greater than 2 × 10 ‐5 mol litre ‐1 . Complete blockade to ganglionic transmission occurred at 3 × 10 ‐4 mol litre ‐1 disopyramide.
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