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Haemodynamic Changes Associated with Atropine/Neostigmine Administration: A Non‐invasive Investigation
Author(s) -
D'Hollander A. A.,
Dewachter B.,
Deville A.,
Vaisiere D.
Publication year - 1981
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1981.tb01635.x
Subject(s) - medicine , atropine , neostigmine , anesthesia , chronotropic , contractility , stroke volume , heart rate , inotrope , hemodynamics , cardiology , blood pressure
Stroke volume, systolic time intervals and related index variations induced by atropine/neostigmine (AN) (0.75 mg/1 mg) decurarization mixture were investigated by non‐invasive methods (ECG, phonocardiogram, thoracic impedance) in 15 anaesthetized normocapnic patients in a stable state after induction of anaesthesia and prior to surgical stimulation. Data showed decrease in mean heart rate (HR) (initial value: 82 beats/min; after 10 min: 57 beats/min; P<0.001) accompanied by an increase in stroke volume (SV) (initial value: 75 ml, after 10 min: 100 ml; P<0.001). No alterations in myocardial contractility were noted with the systolic time intervals (PEP, PEP/LVET, 1 /PEP2). Under the conditions of the study, the negative chronotropic effect of AN mixture was not accompanied by a negative inotropic state.