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Pentoxifylline Does Not Protect Mice Against Hypoxia
Author(s) -
Steen P. A.,
Michenfelder J. D.
Publication year - 1981
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1981.tb01630.x
Subject(s) - medicine , pentoxifylline , hypoxia (environmental) , pharmacology , anesthesia , oxygen , chemistry , organic chemistry
Pentoxifylline 12.5–200 mg/kg failed to increase the survival time of mice exposed to oxygen, 5%. Other measures have previously been shown to increase survival time in this model, probably by improving the ratio of energy supply to demand. This has been accomplished by either increasing cerebral blood flow or decreasing cerebral energy consumption. Contrary to previous reports, it thus seems unlikely that pentoxifylline favorably affects these factors, at least in this model.