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Influence on Cerebral Blood Flow of Infusion of Sodium Bicarbonate during Respiratory Acidosis and Alkalosis in the Dog
Author(s) -
Arvidsson S.,
Häggendal E.,
Winsö I.
Publication year - 1981
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1981.tb01625.x
Subject(s) - medicine , cerebral blood flow , respiratory alkalosis , alkalosis , respiratory acidosis , hypercapnia , anesthesia , acidosis , sodium bicarbonate , metabolic alkalosis , bicarbonate , respiratory system , vasoconstriction , metabolic acidosis , chemistry
In anaesthetized dogs, a mixed acid‐base disturbance was induced by adding a pronounced metabolic alkalosis to an established respiratory acidosis or alkalosis. Cerebral blood flow (CBF) was measured by the radioisotope washout method. In the hypocapnic dogs, the addition of metabolic alkalosis did not significantly change cerebral blood flow. In the hypercapnic dogs, the intravenous infusion of alkali led to a substantial reduction of cerebral blood flow, parallelled by a reduction of cerebrovenous oxygen tension. Acid‐base analysis of cerebrospinal fluid (CSF) indicated an increased bicarbonate concentration. Hypercapnia is suggested to facilitate the passage of bicarbonate over the blood‐brain barrier, leading to cerebral vasoconstriction by means of increased extravascular pH.