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Bioavariability of Rectal Aspirin in Neurosurgical Patients
Author(s) -
Kanto J.,
Klossner J.,
Mäntylä R.,
Yrjänä T.
Publication year - 1981
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1981.tb01600.x
Subject(s) - medicine , aspirin , rectal administration , anesthesia , rectum , oral administration , surgery
Serum salicylate levels were determined fluorometrically in 12 neurosurgical patients after rectal and oral administration of 1.0 g aspirin. There was no significant difference in the AUC‐value between the two routes of administration, but a slower rate of absorption with no clear peak effect was found after rectal administration. Rectal aspirin is useful in clinical situations in which medication is difficult by the oral route, e.g. after neurosurgical and open‐heart surgical interventions.