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Cardiovascular Effects of Sodium Nitroprusside in Cerebral Aneurysm Surgery
Author(s) -
Lagerkranser M.,
Gordon E.,
Rudehill A.
Publication year - 1980
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1980.tb01577.x
Subject(s) - medicine , sodium nitroprusside , aneurysm , anesthesia , cardiology , surgery , nitric oxide
Cardiovascular eflects of sodium nitroprusside (SNP) were studied in 17 patients undergoing cerebral aneurysm surgery under controlled hypotension. In 10 patients oxygen uptake was also calculated. Mean arterial bood pressure was decreased from 91 to 58 mmHgby SNP due to reductions in both total peripheral resistance (29%) and cardiac output (15%). Mean right atrial and pulmonary capillary wedge pressures were reduced during hypotension. Total oxygen uptake remained constant throughout the procedure. There was no signilicant change in arterial oxygen tension in the hypotensive period, but after discontinuation of SNP infusion it was significantly increased. The haemodynamic effects of SNP in patients with a recent subarachnoid haemorrhagc and its etrect on blood oxygenation are discussed. It is concluded that the fall in cardiac output is related to a reduction of central blood volume and might be more pronounced in these patients than in normal subjects.