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Incubation Conditions and Reversibility of a New Non‐Depolarizing Neurornuscular Blocking Agent, Org‐NC45
Author(s) -
Krieg N.,
Mazur L.,
Booij L. H. D. J.,
Crul J. F.
Publication year - 1980
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1980.tb01576.x
Subject(s) - medicine , blocking (statistics) , incubation , neuromuscular blocking agents , depolarization , pharmacology , anesthesia , biochemistry , computer network , chemistry , computer science
We describe the clinical use, for intubation purposes, of Org‐NC45, a new non‐depolarizing neuromuscular blocking agent. Administration of 50 and 72 μg/kg of this drug allowed good to excellent endotracheal intubation conditions within 3 and 2 min, respectively. In none of the cases was a signifcant change in blood pressure or heart rate seen after the injection of Org‐NC45. The resulting block was of short duration and, if necessary, was easily reversed with neostigmine or pyridostigmine.