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Epidural Opiate and Perioperative Analgesia
Author(s) -
Dirksen R.,
Nijhuis G. M. M.
Publication year - 1980
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1980.tb01565.x
Subject(s) - medicine , opiate , nociception , anesthesia , perioperative , morphine , receptor
Epidural injections of 5 mg nicomorphine in 20 ml 5% glucose were given to 10 gynaecological patients to provide intra‐operative and post‐operative analgesia. Signs of changed nociception appeared within 5 min. The maximum change occurred within 20 min. Effectiveness was at least 31/2 h. After an observation period of 30 min, light general anaesthesia is supplemented to give excellent operating conditions. It is suggested that opiates produce these effects by a direct action on the endorphin “pain” modulatory system of human beings at spinal level.