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Skeletal Muscle Oxygen Pressure Fields in Healthy Human Volunteers: A Study of the Normal State and the Effects of Different Arterial Oxygen Pressures
Author(s) -
Lund N.,
Jorfeldt L.,
Lewis D. H.
Publication year - 1980
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1980.tb01548.x
Subject(s) - medicine , oxygen , oxygenation , forearm , plethysmograph , blood pressure , blood flow , mean arterial pressure , arterial blood , anatomy , anesthesia , heart rate , chemistry , organic chemistry
The MDO (Mehrdraht Dortmund Oberfläche) oxygen electrode was used for studies of tissue oxygen pressure fields (presented as histograms) in healthy human volunteers breathing room air and gas mixtures with different oxygen concentrations. Forearm blood flow measurements were performed with strain gauge plethysmography, and local blood flow and permeability‐surface area product (PS) were studied by the clearances of 133 xenon and 51 Cr‐EDTA. At ordinary arterial oxygen pressure levels the histograms were normal, i.e. their distribution type was approximately Gaussian. Higher arterial oxygen pressures caused changes in tissue oxygenation. However, at arterial oxygen pressure levels above 31 kPa two types of abnormal histogram distribution types were distinguished: scattered multi‐population histograms (type a) and a type with predominantly low values (type b). Mean forearm blood flow showed only minor variations, whereas the clearances of 133 xenonand and 51 Cr‐EDTA were higher with higher PaO 2 . A parallel increase was also seen in PS.