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The Pulmonary Vasoconstrictor Response to Hypoxia during Enflurane Anesthesia
Author(s) -
Bjertnæs L. J.,
Mundal R.
Publication year - 1980
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1980.tb01545.x
Subject(s) - enflurane , halothane , medicine , hypoxia (environmental) , methoxyflurane , diethyl ether , anesthesia , lung , hypoxic pulmonary vasoconstriction , oxygen , chromatography , chemistry , organic chemistry
Previous investigations have shown that diethyl ether, halothane and methoxflurane inhibit the vasoconstrictor response to hypoxia in isolated rat lungs. A damping effect of diethyl ether and halothane has been observed in the human lung as well. In the intact dog lung, however, other workers have recently denied any effect of halothane and enflurane on this vasoconstrictor mechanism. These findings challenged us to investigate the effect of enflurane on the vasoconstrictor response to hypoxia in isolated rat lungs. We found that enflurane administered via the airways reduced the response in proportion to the end‐tidal concentration of enflurane, as determined by mass spectrometry.