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Reduction of the Risk of Acid Pulmonary Aspiration in Anaesthetized Patients after Cimetidine Prernedication
Author(s) -
Salmenperå M.,
Korttila K.,
Kalima T.
Publication year - 1980
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1980.tb01499.x
Subject(s) - cimetidine , medicine , premedication , placebo , anesthesia , pulmonary aspiration , randomized controlled trial , surgery , alternative medicine , pathology
Forty‐two patients undergoing elective general surgery received either placebo, cimetidine 300 mg, or cimetidine 600 mg orally 1.5–2 h before anaesthesia in a double‐blind, randomized study. Another 13 subjects received no oral premedication and served as a control group. When compared to placebo or control patients, both doses of cimetidine significantly (P< 0.01) decreased the acidity and volume of gastric contents. None of the subjects given cimetidine were in the risk range of acid pulmonary aspiration (pH under 2.5 plus volume over 25 ml), whereas 46% of the control patients and 40% of the patients given placebo (P<0.005 vs cimetidine in both groups) were in the risk range.