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Fluoride Kinetics and Renal Function During Enflurane Anaesthesia
Author(s) -
Jårnberg P.O.,
Ekstrand J.,
Irestedt L.,
Santesson J.
Publication year - 1979
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1979.tb05468.x
Subject(s) - enflurane , medicine , fluoride , excretion , renal function , reabsorption , renal physiology , anesthesia , fractional excretion of sodium , isoflurane , sodium fluoride , endocrinology , kidney , chemistry , inorganic chemistry
Renal function, fluoride formation and excretion were studied during and after enflourane anaesthesia in seven patients. During anaesthesia, urine flow rate, inulin clearance, PAH clearance and fractional sodium excretion were 13, 78, 65 and 49“., of control values, respectively. Renal function was promptly restored postoperatively. Enflurane was metabolized to inorganic fluoride with a mean maximal serum level of 17.4 k 3.3 μM. Fractional Huoride excretion decreased during anaesthesia to 35% of the control value. Postoperatively, them was a highly significant correlation between the increase in fractional fluoride excretion and the rise in urinary pH during two consecutive 3‐hour periods. It is suggested that tubular reabsorption of fluoride is inversely related to tubular fluid pH and that fluoride is reabsorbed by non‐ionic diffusion.