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Effects of Enflurane Anesthesia on the Function of Ischemically Damaged Kidneys
Author(s) -
Wickström I.
Publication year - 1979
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1979.tb05467.x
Subject(s) - medicine , enflurane , anesthesia , halothane
Enflurane is metabolizcd to inorganic fluoride. Serum levels of inorganic fluoride exceeding 50 pM/l are considered nephrotoxic for normal kidneys. Renal damage has not been observed after enflurane anesthesia in patients with normal renal function. Further impairment in patients with previously damaged kidneys has been reported. The restitution of function of is chemically damaged kidneys was studied in two groups of dogs. In one of the groups, dogs were submitted to a long duration enflurane anesthesia. The other group served as a control. In the first group the serum level of inorganic fluoride at the end of the anesthesia was 27.9 pM/L Renal function was studied with endogenous clearances and concentration capacity. The inorganir fluoride level achieved by enflurane anesthesia did not influence the restitution of renal function.