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Comparative Potency and Speed of Onset of Fazadinium and d‐Tubocurarine
Author(s) -
Hussain S. Z.,
Healy T. E. J.,
Birmingham A. T.
Publication year - 1979
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1979.tb01459.x
Subject(s) - d tubocurarine , medicine , potency , tetanus , pharmacology , anesthesia , toxicology , immunology , biochemistry , in vitro , chemistry , vaccination , biology
The potency and speed of onset of fazadinium and d‐tubocurarine have been compared at three cumulative doses. With thiopentone as the induction agent, the dose ratio fazadinium/d‐tubocurarine ranged from 1.2 to 1.3 for single twitch reduction and from 1.1 to 1.2 for reduction of tetanus. The times taken for the development of 50% and 100% effect after each dose increment were not significantly different for the three doses of fazadinium and the 2nd and 3rd doses of d‐tubocurarine. However, the 1st dose of d‐tubocurarine was markedly slower than fazadinium to achieve a 50% and 100% effect.