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Effect of Different Anesthetics on the Pharmacokinetics and Pharmacodynamics of Pancuronium in the Cat
Author(s) -
Miller R. D.,
Agoston S.,
Pol F.,
Booij L. H. D. J.,
Crul J. F.
Publication year - 1979
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1979.tb01453.x
Subject(s) - enflurane , medicine , halothane , anesthesia , ketamine , neuromuscular blockade , pharmacokinetics , pharmacodynamics , pentobarbital , pharmacology
To investigate the effect of different anesthetics on the pharmacokinetics and pharmacodynamics of pancuronium, 120 μg/kg i.v., cats were anesthetized with either pentobarbital (N = 4), ketamine (N = 4), enflurane (N = 5), or halothane (N = 5). A longer onset time and duration of neuromuscular blockade occurred during enflurane and halothane anesthesia. The apparent elimination half‐life was longer and the total volume of distribution at steady state larger during halothane anesthesia. The plasma concentration of pancuronium required for neuromuscular blockades was less during enflurane than during the other three anesthetics. We conclude lhat inhalation anesthetics may prolong a neuromuscular blockade by altering both the pharmacokinetics and pharmacodynamics of pancuronium.