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Regional Lung Function and Central Hemodynamics Following Normovolemic Hemodilution in the Dog
Author(s) -
Rosberg B.
Publication year - 1979
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1979.tb01433.x
Subject(s) - medicine , hemodynamics , anesthesia , oxygenation , cardiac output , central venous pressure , blood volume , oxygen transport , lung , dextran , arterial oxygen tension , ventilation (architecture) , blood pressure , oxygen , heart rate , mechanical engineering , chemistry , organic chemistry , engineering , biochemistry
Regional lung fnnction, using xenon 133 ‐radiospirometry, and central hemodynamics were stndied following normovolemic hemodilution with dextran 70. Normovolemic hemodilution to hematocrit values of 25% increased cardiac output and pulmonary blood volume significantly. The systemic oxygen transport and mixed venous oxygen tension were unchanged. The acute hemodilution did not significantly change the distribution of ventilation or perfusion within the lungs. It is hypothesised that a tendency to an increase in arterial oxygenation is due to a reduced interstitial pressure in the basal region of the lungs, resulting from water absorption by the hyperoncotic dextran used for hemodilution.