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The Circulatory Effects of Intravenously Administered Ephedrine during Epidural Blockade
Author(s) -
Engberg Greta,
Wiklund Lars
Publication year - 1978
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1978.tb01351.x
Subject(s) - medicine , ephedrine , anesthesia , premedication , blockade , vascular resistance , heart rate , epinephrine , stroke volume , cardiac output , circulatory system , blood pressure , cardiology , hemodynamics , receptor
The changes in central circulation following a small dose of intravenously administered ephedrine were Ftudicd in middle‐aged and elderly patients during high epidural blockade with bupivacainc 0.5% with adrenaline, etidocaine 1% with adrenaline, and etidocaine 1% plain. Intravenously injected ephedrine restored the mean, systolic and diastolic arterial blood pressures to the preanalgesic value independent of the degree of hypotension, and was not followed by marked hypcrtcnsion in any case. Although the heart rate did not change, the cardiostimulatory effects were more pronounced than after subcutaneous premedication, resulting in increased stroke volume and cardiac output in all groups. Peripheral vascular resistance increased to the preanalgesic value in the groups receiving bupivacaine adrenaline and etidocaine plain. In the etidocaine adrenaline group, peripheral vascular resistance was little changed, as the cardiostimulatory effects were more pronounced than in the other groups.