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In Vivo Lung Uptake of Lidocaine in Pigs
Author(s) -
Bertler ÅKe,
Lewis David H.,
Löfström J. Bertil,
Post Claes
Publication year - 1978
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1978.tb01335.x
Subject(s) - lidocaine , medicine , lung , bolus (digestion) , pulmonary artery , in vivo , anesthesia , blood pressure , nuclear medicine , biology , microbiology and biotechnology
A mixture of 14 C‐labelled lidocaine and indocyanine green dye (IG) (Cardiogreen®) was injected as a bolus into the pulmonary artery in pigs (15–25 kg). Time‐concentration curves for both substances were constructed from 2/s blood samples taken from the common carotid artery for approximately 20 s. The extraction of lidocaine in each sample and the 95% first passage uptake (FPU) were calculated, assuming that IG is inert with respect to the lung and that it remains within the vascular compartment. The IG curves were also used to calculate cardiac output. The acid‐base status and arterial blood pressure or ECG were also followed. Earli animal was given two injections. When 0.5 mg/kg b.w. lidocaine was injected, FPU was 41±3%; at a dose of 2 mg/kg b.w., FPU was 28±3% ( P <0.05). The initial extraction during the first 2 s after appearance of the substances was approximately 80%. This level declined with subsequent samples, and the decline was equally rapid at both dose levels.