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The Effect of Acute Respiratory Acidosis on the Proportion: Total Splanchnic Perfusion/Cardiac Output, and the Alteration in this Proportion by Two Anaesthetics
Author(s) -
Juhl B.,
EinerJensen N.
Publication year - 1978
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1978.tb01329.x
Subject(s) - medicine , splanchnic , halothane , perfusion , anesthesia , acidosis , respiratory acidosis , cardiac output , vascular resistance , respiratory system , hemodynamics
Eight dogs were anaesthetized and ventilated. Respiratory acidosis with variations in the pH (range: 7.49 to 7.05) were brought about by changes in the dead space of the apparatus. The pH‐related changes in cardiac output ( Q ), and total splanchnic perfusion (Q sp1 ) were studied during anaesthesia with mebumal natrium (NFN) N 2 O‐O 2 ‐gallamoni jodidum (NFN) (“basic anaesthesia”), and after the addition of 1 % halothane (inspiratory). Similar relationships were demonstrated in the systemic circulation between pH changes and changes in the cardiac output, pulse pressure, and total peripheral resistance during both types of anaesthesia; whereas the pulse frequency and the mean aorti cpressure were not significantly correlated to changes in pH. Q sp1 was different during the two types of anaesthesia. Under “basic anaesthesia,” the pH‐related changes in Q and Q sp1 were opposite and of varying magnitude. Their mutual relation: the fraction of cardiac output perfusing the splanchnic area, was Q sp1 /Q= ‐2.28 + 0.34×pH (r = 0.69, N = 28, P <0.001). After the addition of halothane, no correlation could be demonstrated between Q sp1 /Q and changes in pH. The changes in Q and Q sp1 were in the same direction and of the same relative magnitude, with an average of Q sp1 /Q = 0.21. In agreement with this, no changes could be demonstrated in the total splanchnie resistance (R sp1 ) during halothane anaesthesia in relation to the provoked pH changes, while R sp1 under “basic anaesthesia” showed a slight rise with falling pH in the majority of dogs (six out of eight). The pressure in the portal vein (P vp ) appeared to rise with a falling pH. For both types of anaesthesia, the AP vp (kPa) = ‐0.97 × δpH (r = 0.79, N = 34, P <0.001).