Premium
The Effect of Surgical Stress on Haemodynamics During Neurolept Anaesthesia
Author(s) -
Santesson Joakim,
Järnberg PerOlof,
Arnér Staffan
Publication year - 1978
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1978.tb01289.x
Subject(s) - medicine , hemodynamics , anesthesia , surgical stress
The influence of surgical stress on haemodynamics during neurolept anaesthesia (NLA) was studied in ten patients, while they were awake, under anaesthesia prior to surgery and peroperatively. Systemic arterial, pulmonary arterial, right atrial and pulmonary capillary wedge pressures, as well as cardiac output (Q t ), arterial oxygen content and mixed venous oxygen content, were measured. Systemic and pulmonary vascular resistances, arterial‐venous oxygen content difference (AVD), oxygen consumption (v o2 and cardiac index (CI) were calculated. On institution of anaesthesia, CI fell from 2.8 ±.11 /min. m 2 to 2.5±0.2 l /min.m 2 and systolic arterial pressure (SBP) fell from 13.4±0.5 kPa to 10.2±0.3 kPa. During surgery CI rose to 3.3±0.1 1/min.m 2 and SBP rose to 15.7±0.6 kPa. Prior to anaesthesia, AVD was 40.2±0.2 ml/l Under anaesthesia prior to surgery, AVD did not change, but v O2 declined from 207±13 ml/min to 171±10 ml/min. During surgery, AVD fell to 30.5±0.3 ml/l, while V o2 remained unchanged. It is concluded that NLA has a direct metabolic depressant effect and, in association with surgery, is accompanied by hyperkinetic circulation.