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Reduction of Cerebral Blood Flow and Oxygen Consumption with a Combination of Barbiturate Anaesthesia and Induced Hypothermia in the Rat
Author(s) -
Nordström C.H.,
Rehncrona S.
Publication year - 1978
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1978.tb01272.x
Subject(s) - medicine , barbiturate , hypothermia , anesthesia , cerebral blood flow , blood flow , oxygen , cardiology , chemistry , organic chemistry
The influence of phenobarbitone anaesthesia on cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRo 2 ) during hypothermia (23°C & 27°C) was studied in the rat, using a modification of the K ety & S chmidt (1948) technique and arterio‐venous differences for oxygen. Phenobarbitone (150 mg/kg) was found to decrease CMRo 2 by 40–60% during hypothermia, when compared to N 2 O anaesthesia. At a body temperature of 23°C, and during phenobarbitone anaesthesia, CMRo 2 was reduced to about 15% of normal control value (about 10.3 ml.100g ‐l . min ‐l ). CBF was reduced to about 50% of the phenobarbitone control value but was similar to the value obtained with N 2 O anaesthesia at 22°C. It is concluded that the combination of phenobarbitone anaesthesia and hypothermia results in a more pronounced reduction in cerebral metabolic rate for oxygen than can be achieved by administration of barbiturates to normothermic animals, or by reducing body temperature by 15°C during superficial anaesthesia.