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Immunosuppression after Cholecystectomy
Author(s) -
Salo M.,
Eskola J.
Publication year - 1977
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1977.tb01253.x
Subject(s) - medicine , immunosuppression , cholecystectomy , intensive care medicine , medline , general surgery , political science , law
The effect on immune functions of cholecystectomy under combined anaesthesia was studied in nine patients. The parameters examined were the leucocyte and differential count, the T‐ and B‐lvmphocyte count, and the lymphocyte transformation induced by phytohaemagglutinin, concanavalin A, pokeweed mitogen and purified protein derivative of tuberculoprotein. The anaesthesia and operation decreased the total lymphocyte count in the peripheral blood. No significant change occurred in the proportion or absolute number of E‐binding (T) lymphocytes. The proportion of EAC‐binding (B) lymphocytes increased, although no change was observed in the lymphocytes with surface immunoglobulin representing another B‐cell marker. A statistically significant decrease was found in the lymphocyte response to all the mitogens used both in cultures with isolated lymphocytes and in whole blood. The changes returned to the pre‐induction level on the third postoperative day. These findings suggest a transitory decrease of cellmediated immunity after cholecystectomy.