Premium
The Haemodynamic Effects of Nitrous Oxide Anaesthesia on Systemic and Pulmonary Circulation in Dogs
Author(s) -
Dottori O.,
Häggendal E.,
Linder E.,
Nordström G.,
Seeman T.
Publication year - 1976
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1976.tb05061.x
Subject(s) - nitrous oxide , hyperoxia , medicine , contractility , anesthesia , vascular resistance , inotrope , cardiac output , hemodynamics , heart rate , oxygen , cardiology , blood pressure , lung , chemistry , organic chemistry
The haemodvnamic effects of nitrous oxide in normoxia (20% oxygen) and in hyperoxia (50% oxygen) were investigated in 13 dogs. Nitrous oxide in hyperoxia caused a significant rise in total peripheral resistance and a significant decrease in cardiac output, heart rate, myocardial contractility (dP/dt max) and cardiac worl?. On the other hand, nitrous oxide in normoxia seemed to reverse these findings and did not exert any negative inotropic effects on the myocardium. The results indicate that the earlier reported sympathetic activation of the circulation may be related to hyperoxia and not to nitrous oxide as such.