Premium
Restoration of Oxygen Uptake and Blood Flow in the Rat Cerebral Cortex after Halothane Anaesthesia
Author(s) -
Berntman Leif,
Carlsson Christer,
Siesjö Bbo K.
Publication year - 1976
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1976.tb05054.x
Subject(s) - medicine , halothane , anesthesia , cerebral blood flow , oxygen , blood flow , cerebral cortex , cardiology , chemistry , organic chemistry
Halothane decreases both the certal blooi Row (CBF) and the cerebral metabolic rate for oxygen (CMRo 2 ) when given in anaesthetic doses. A recent report (G jedde & H indfelt 1975) suggests that when halothane is administered to rats for 1 hour, CBF and CMRo 2 are depressed by about 30 and 40%, respectively, for as long as 4 hours after discontinuation of the halothane anaesthesia. In the present study rats were anaesthetized with 1% halothane for 1 hour, and CBF and CMRo 2 were measured at the end of a 30 min recovery period, during which 70% N 2 O was administered. Comparison with animals maintained on 70% N 2 O throughout the entire 90 min period showed that previous halothane anaesthesia had no effects on CBF or CMRo 2 .