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Reduction of Psychotomimetic Side Effects of Ketalar® (Ketamine) by Rohypnol®(Flunitrazepam) A Randomized, Double‐Blind Trial
Author(s) -
Freuchen I.,
øSjstergaard J.,
Kuhl J. B.,
Mikkelsen B. O.
Publication year - 1976
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1976.tb05015.x
Subject(s) - ketamine , flunitrazepam , medicine , anesthesia , psychotomimetic , placebo , blood pressure , benzodiazepine , nmda receptor , receptor , alternative medicine , pathology
A double‐blind controlled trial based on 140 women undergoing abortus provocatus was employed to study whether the frequency of side effects after administration of the anaesthetic Ketalar®(ketamine) could be reduced by a concurrent dose of Rohypnol® (flunitrazepam). The control group was given ketamine alone. The dosage of ketamine was 2 mg/kg body weight, supplemented if necessary by 1 mg/kg, in combination with either 2 mg flunitrazepam or placebo. No other anaesthetics were used. On several counts, the combination of ketamine and flunitrazepam was proved to reduce the adverse reactions seen with ketamine alone. Motor restlessness and confusion in the awakening state occurred with significantly less severity and frequency. Amnesia for dreams was significantly more frequent. Memory of dreams was often unpleasant after ketamine alone. The influence on pulse rate was significantly smaller and no significant changes in systolic blood pressure were seen, whereas a significant increase occurred with ketamine alone. Less pronounced fluctuations in diastolic blood pressure occurred with the combination ketamine‐flunitrazepam. Respiratory rate increased significantly with both treatments, but respiratory minute volume was lower with the ketamine‐flunitrazepam combination.