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Halothane‐Induced Liver Damage: An Analysis of the Material Reported to the Swedish Adverse Drug Reaction Committee, 1966–1973
Author(s) -
Böttiger L. E.,
Dalén E.,
Hallén B.
Publication year - 1976
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1976.tb05007.x
Subject(s) - halothane , medicine , drug , liver injury , anesthesia , adverse effect , liver damage , bilirubin , food and drug administration , adverse drug reaction , drug reaction , serum bilirubin , pharmacology , gastroenterology
An analysis of 94 reports to the Swedish Adverse Drug Reaction Committee of patients with liver injury after surgery and halothane anaesthesia (including 13 fatal cases) has not been able to reveal any other factors responsible for the liver injury than the halothane administration. Eighty‐two per cent of the total material and 12 out of 13 fatal cases had had multiple exposures. Our results suggest that the liver injury becomes more severe after repeated exposures; maximum serum bilirubin and SGOT values are higher after an increasing number of halothane exposures.