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A Simple Technique for the Determination of the Ventilatory Response to Rising Arterial CO 2 Tensions, Suitable for Patients with Neurological Disorders
Author(s) -
Brandt Lars,
Granholm Lars,
Thomson Dick
Publication year - 1975
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1975.tb05410.x
Subject(s) - medicine , anesthesia , ventilation (architecture) , breathing , respiration , pneumonia , meteorology , physics , anatomy
Patients with neurological disorders may have a reduced ventilatory response to a rising PaCO 2 . This is often unpredictable and may become apparent only when other complications, e.g. infections (pneumonia), occur or when the patient is subjected to general anaesthesia. This paper describes a simple method suitable for screening patients who may have an impaired capacity of eliminating CO 2 when stressed. Ventilatory changes were determined during the continuous recording of the CO 2 concentration in end‐tidal air in 20 healthy subjects, who were breathing first air and then gas mixtures containing 21% O 2 and 2.5 or 5% CO 2 . A prediction interval with 90 and 95% probability limits was constructed for healthy individuals. The normally expected change in minute ventilation per m 2 body surface area per change in PACO 2 (ΔV E /m 2 , l/min/ΔPACO 2 ) for this technique is also given.