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The Effect of Phenobarbitone Anaesthesia on Blood Flow and Oxygen Consumption in the Rat Brain
Author(s) -
Nilsson Lorentz,
Siesjó Bo K.
Publication year - 1975
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1975.tb05408.x
Subject(s) - medicine , fentanyl , anesthesia , cerebral blood flow , blood flow , oxygen , chemistry , organic chemistry
The influence of phenobarbitone anaesthesia on blood flow (CBF) and oxygen consumption (CMR o2 ) was evaluated in the rat brain, using a method that quantitatively measures CBF in mainly cortical areas. The data were compared to those obtained in animals under fentanyl citrate analgesia. Body temperature and arterial CO 2 tension were maintained close to normal values in all groups. With 50 mg/kg of phenobarbitone, CBF and CMR O2 were reduced by about 20 %. With 150 or 250 mg/kg, further reductions in CBF and CMR O2 were observed. At 250 mg/kg, CBF was reduced to one third, and CMR O2 to about 50 % of normal. The results suggest that little further reduction in CBF or CMR O2 can be expected if the dose of phenobarbitone is increased above 250 mg/kg.