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Side Effects and Skills Related to Driving After Intramuscular Administration of Bupivacaine and Etidocaine
Author(s) -
Korttila K.,
Häkkinen S.,
Linnoila M.
Publication year - 1975
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1975.tb05200.x
Subject(s) - medicine , bupivacaine , anesthesia , flicker fusion threshold , psychomotor learning , placebo , saline , intramuscular injection , flicker , psychiatry , cognition , electrical engineering , alternative medicine , pathology , engineering
Eleven healthy subjects were injected intramuscularly with a saline placebo, 1.3 mg/kg of 0.5% plain bupivacaine, or 2.6 mg/kg of 1.0% plain etidocaine in a double‐blind cross‐over fashion. Before and at 1/2, 2 and 4 h after injection, side effects were recorded, and psychomotor skills related to driving were measured. Fatigue, dizziness, and sore thighs were significantly more common with etidocaine than with bupivacaine or the saline solution. Bupivacaine significantly impaired eye‐hand coordination and flicker fusion discrimination during the whole observation period. Etidocaine impaired flicker fusion discrimination only. The subjects' adaption to darkness, sensitivity to brightness, and visual discrimination ability in bright counterlight remained unaltered after each treatment. The results suggest that such psychomotor performance as driving ability is impaired for at least 2 h after a patient receives 1.3 mg/kg of plain bupivacaine or 2.6 mg/kg of plain etidocaine intramuscularly. ZUSAMMENFASSUNG Lokalanaesthetika werden für ambulatorische Anarsthesien empfohlen (S oehring & W olter 1968), vor allem weil sie angeblich die Psychomotorik des Patienten unbeeinflußt lassen. In einer kürzlich erschienenen Untersuchung (K orttila 1974) war die reaktive Geschicklichkeit 30‐90 Minuten nach einer i.m. Injektion von einfachem Lidocain gestört. Da es keine Berichte über psychomotorische Keaktionen nach der Anwendung langwirkender Lokalanaesthetika gibt, wurde die vorliegende Untersuchung durchgeführt, um die psychomotorische Geschicklichkeit nach i.m. Injektionen von Bupivacain und von Etidocain zu messen. Ein weiterer Zweck dieser Studie war der Vergleich der Nebenwirkungen dieser beiden Lokalanaesthetika.