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Malignant Hyperthermia in a Family: A Clinical and Serological Investigation of 139 Members
Author(s) -
Kelstrup J.,
ReskeNielsen E.,
Haase J.,
Jørni J.
Publication year - 1974
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1974.tb00700.x
Subject(s) - medicine , creatine kinase , malignant hyperthermia , hyperthermia , general anaesthesia , serology , intensive care medicine , anesthesia , surgery , immunology , antibody
In a family of 147 members, two have died from malignant hyperthermia induced by general anaesthesia, and six from other causes. The remaining 139 family members have all been examined clinically and serologically. Forty per cent of the family members had musculoskeletal disorders and 30% had elevated values of creatine phosphokinase in serum. The mode of inheritance is shown not to be autosomal dominant. Doubt is expressed concerning the value of the determination of creatinine phosphokinase (CPK) in serum. It is concluded that it is uncertain whether such determination can predict the risk of the individual patient for developing malignant hyperthermia. Emphasis is laid upon prophylaxis by issuing cards to members of families at risk, by questioning all patients preoperatively about anaesthesiological complications among family members, and by temperature monitoring. It is suggested that any case of malignant hyperthermia give rise to investigation of the family.