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The Effect of Halothane on the Neuromuscular Blocking Action of Pancuronium (Pavulon®)
Author(s) -
Barth Lothar
Publication year - 1972
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1972.tb00576.x
Subject(s) - medicine , halothane , anesthesia , pancuronium bromide , neuromuscular blocking agents , neuromuscular blockade
By means of electromyographic investigation in man it could be demonstrated that halothane administered during recovery from neuromuscular block of pancuronium does not exert any measurable synergistic action to pancuronium. Halothane, therefore, may be combined freely with pancuronium in anaesthetic practice. In contrast to other non‐depolarising muscle relaxants there is no need to reduce the dose of either the relaxant or the anaesthetic (or both) when halothane and pancuronium are used together. ZUSAMMENFASSUNG Mittels elektromyographischer Untersuchungen am Menschen konnte bewiesen werden, daß Halothan‐verabreichung wöhrend der Erholungsphase nach neuromuskulärer Blockade durch Pancuronium keinen meßbaren synergistischen Effekt zu Pancuronium hat. Halothan kann daher in der Anaesthesiepraxis uneingeschränkt mit Pancuronium kombiniert werden. Im Gegensatz zu anderen nichtdepolarisierenden Muskelrelaxantien muß weder die Dosis des Relaxans noch die des Anaesthetikums (oder beider) reduziert werden, wenn man Halothan und Pancuronium gemeinsam verwendet.