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THE NUTRITIVE EFFECT IN MAN OF NON‐ESSENTIAL AMINO ACIDS INFUSED INTRAVENOUSLY (TOGETHER WITH THE ESSENTIAL ONES)
Author(s) -
Vinnars Erik,
Fürst Peter
Publication year - 1970
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1970.tb00968.x
Subject(s) - nitrogen balance , amino acid , nitrogen , medicine , urea , zoology , chemistry , biochemistry , biology , organic chemistry
SUMMARY The nitrogen balance, the nutritive value and the excretion of urea nitrogen were studied in healthy volunteers to whom I‐amino acid solutions were infused intravenously. The volunteers were on a standard nitrogen‐poor diet with a high caloric value. The infused solutions contained 10 or 14 g of amino acid nitrogen per daily dose. The ratio between essential and non‐essential amino acids was varied. It was found that the results, when 14 g of nitrogen was infused, were not superior to those widi 10 g of nitrogen. The balance was higher when 23 per cent of the amino acid nitrogen was constituted by nitrogen from essential amino acids, on the 10 g of nitrogen level, than when 17 or 35 per cent were provided from the same source, although these differences were not statistically significant. But the percentage of essential nitrogen seemed to be of little influence on the balance. ZUSAMMENFASSUNG Die Stickstoffbilanz, der Nahrwert und die Ausscheidung von Harnstoff‐stickstoff wurde bei gesunden Versuchspersonen untersucht, denen 1‐Amino‐saurelosungen intravenos infundiert wurden. Die Freiwilligen erhielten eine stick‐stoffarme Standarddiat von hohem Kalorienwert. Die infundierten Losungen enthielten 10 oder 14 g Aminosaurestickstoff als Tagesdosis. Das Verhaltnis zwischen essentiellen und nicht essentiellen Aminosauren wurde variiert. Es zeigte sich, dass die nach Infusion von 14 g Stickstoff gefundenen Resultate denen nach 10 g Stickstoff nicht iiberlegen waren. Wenn der Anteil an essentiellen Aminosauren vom Gesamt‐Aminosaurestickstoff 23% betrug, waren die Ergebnisse besser als bei 17 bzw. 35% essentiellen Aminsaurestickstoff; aller‐dings waren die Unterschiede statistisch nicht significant.