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Methemoglobin in man Following the use of Prilogaine
Author(s) -
Crawford Oral B.
Publication year - 1965
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1965.tb00539.x
Subject(s) - methemoglobin , medicine , methemoglobinemia , prilocaine , dose , metabolite , hypoxia (environmental) , methylene blue , anesthesia , hemoglobin , oxygen , toxicology , pharmacology , physiology , biochemistry , local anesthetic , chemistry , organic chemistry , photocatalysis , biology , catalysis
SUMMARY We have demonstrated in clinical practice that (1) a dose‐response relationship exists between the dose of prilocaine and the incidence of methe‐moglobin, (2) the methemoglobin is probably related to a metabolite of prilocaine and not to the agent itself, (3) dosages of prilocaine in excess of 16 mg/kg are necessary to produce methemoglobin levels capable of producing symptoms of hypoxia; however, the dosages exceeding 20 mg/kg in this study did not, on these occasions, produce such symptoms of hypoxia, and (4) that dose of 0.5 to 1.0 mg/kg methylene blue can effectively revert methemoglobin levels to normal.