Premium
Further Observations on Xylocaine, an Established Anesthetic Agent, in Comparison to Other “Caines”
Author(s) -
GRUBER LOREN W.
Publication year - 1961
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1961.tb00096.x
Subject(s) - procaine , lidocaine , medicine , local anesthetic , anesthesia , procaine hydrochloride , anesthetic , local anaesthetic
SUMMARY1 An attempt has been made to show that the basic formulae of all hitherto known “local anesthetics” are of the same basic chemical configuration. 2 Their analogues and homologues with their myriad of possibilities can run into the hundreds. 3 The best known and most clinically used local anesthetics have been discussed. Here their strong points, weaknesses and pharmacology have been presented. 4 L. L. 30 (lidocaine, lignocaine, Xylocaine) with its synthesis proves 5 A new principle and not a proprietory product has thus been established. Therefore, the following picture is now coming into sharp focus: Cocaine ← Procaine ← Procaine Derivatives ← Aloxy‐Aminobenzoates ← Xylocaine ← Re‐Introduction of Aloxy‐Aminobenzoates ← Xylocaine.