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EFFECT OF LIDOCAINE ADMINISTERED INTRAVENOUSLY DURING ETHER ANESTHESIA
Author(s) -
Siebecker Karl L.,
Kimmey James R.,
Bamforth Betty J.,
Steinhaus John E.
Publication year - 1960
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1960.tb00067.x
Subject(s) - medicine , anesthesia , lidocaine , ventilation (architecture) , apnea , respiration , respiratory system , anatomy , mechanical engineering , engineering
SUMMARY Twenty patients were anesthetized with ether to a level of plane 3 of surgical anesthesia. Lidocaine (150 mg) was administered intravenously 27 times to these patients, and resulted in apnea on eight occasions. In the other 19 observations the lidocaine administration produced a reduction of mean alveolar ventilation from 136% to 70% of the calculated requirements. The apparent improvement in respiratory pattern which had been observed following lidocaine administration during ether anesthesia was not due to increased ventilation, but rather due to the quiet respiration resulting from further respiratory depression. ZUSAMMENFASSUNG 20 Patienten wurden mit Äther in die dritte Stufe des Toleranzstadiums narkotisiert. 150 mg Lidocain wurde 27‐mal intravenös an diese Patienten verabreicht, wobei 8‐mal eine Apnoe resultierte. Bei den anderen 19 Beobachtungen verursachte die Lidocainverabreichung eine Herabsetzung der mittleren Alveolarventilation von 136% auf 70% des kalkulierten Wertes. Die scheinbare Verbesserung der Atmung, die nach Lidocainverabreichung während der Äthernarkose beobachtet worden war, entspricht also nicht einer vermehrten Ventilation, sondern eher einer ruhigen Atmung als Folge einer weiteren Atemdepression.

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