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EFFECT OF PROCAINE, CARBOCAIN AND XYLOCAINE ON CUTANEOUS MUSCLE IN RABBITS AND MICE
Author(s) -
Brun Arne
Publication year - 1959
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1959.tb00008.x
Subject(s) - medicine , procaine , irritation , atrophy , anesthesia , local reaction , procaine hydrochloride , necrosis , subcutaneous injection , lidocaine , surgery , immunology
SUMMARY The rabbit's skin was studied for its reaction to subcutaneous injection of procaine, xylocaine and carbocain without adrenaline. The histological examination was extended to include an objective recording of the influence of the agent on the muse, cutaneus maximus by measurement of the diameters of the muscle fibres. These three local anaesthetics produced an essentially equally strong subcutaneous inflammatory reaction in concentrations between 0.5 and 2 per cent., while a clear difference was found in the intracutaneous reaction. Xylocaine in concentrations 0.25‐2 per cent, regularly produced inflammation and necrosis in the skin muscle. This reaction increased with the concentration of the agent tested. Two days after the injection of 1–2 per cent, xylocaine definite atrophy of the muscle fibres was demonstrable. Carbocain produced the same effect. Procaine (1–2 per cent.) produced no inflammatory irritation in the musculature and no muscular atrophy. An inflammatory reaction and degenerative changes in the skin musculature after the injection of xylocaine were also seen in mice.