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CARDIOVASCULAR EFFECTS OF PROCAINE AND LIDOCAINE (XYLOCAINE®) DURING GENERAL ANESTHESIA
Author(s) -
Kimmey James R.,
Steinhaus John E.
Publication year - 1959
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1959.tb00002.x
Subject(s) - medicine , lidocaine , procaine , anesthesia , nitrous oxide , blood pressure , vasomotor , depression (economics) , procaine hydrochloride , economics , macroeconomics
SUMMARY The cardiovascular effects of intravenous procaine and lidocaine were compared in two series of patients under nitrous‐oxide‐thiobarbiturate anesthesia. The arterial blood pressure and electrocardiogram of these patients were continuously monitored while standarized doses of 2.2 mg/kg and 1.1 mg/kg of the test drug were administered. It was found that procaine administration was followed by cardiovascular depression in 50 % of the doses administered, while a blood pressure increase was noted following 47 % of the lidocaine injections. The lack of vasomotor depression with the administration of lidocaine is advantageous when this agent is used to supplement general anesthesia.