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Striatal dopamine transporter availability in unmedicated bipolar disorder
Author(s) -
Anand Amit,
Barkay Gavriel,
Dzemidzic Mario,
Albrecht Daniel,
Karne Harish,
Zheng QiHuang,
Hutchins Gary D,
Normandin Marc D,
Yoder Karmen K
Publication year - 2011
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/j.1399-5618.2011.00936.x
Subject(s) - dopamine transporter , dopamine , dopaminergic , dopamine plasma membrane transport proteins , psychology , putamen , neuroscience , medicine , bipolar disorder , oncology , cognition
Anand A, Barkay G, Dzemidzic M, Albrecht D, Karne H, Zheng Q‐H, Hutchins GD, Normandin MD, Yoder KK. Striatal dopamine transporter availability in unmedicated bipolar disorder.
Bipolar Disord 2011: 13: 406–413. © 2011 The Authors.
Journal compilation © 2011 John Wiley & Sons A/S. Objectives: Dopamine transmission abnormalities have been implicated in the etiology of bipolar disorder (BPD). However, there is a paucity of receptor imaging studies in BPD, and little information is available about the dopamine system in BPD. Reuptake of synaptic dopamine by the dopamine transporter (DAT) is the principal mechanism regulating dopamine neurotransmission, and is often used as a marker for presynaptic dopamine function. This positron emission tomography (PET) study investigated whether DAT availability differed between BPD and healthy control subjects. Methods: A total of 11 unmedicated BPD patients in either the euthymic or depressed phase and 13 closely matched healthy subjects underwent PET imaging with the DAT‐selective radiotracer [ 11 C]CFT and a structural magnetic resonance imaging (MRI) scan. Striatal binding potential (BP ND ) was estimated using the multilinear reference tissue model. Region of interest and analyses were conducted to test for differences in [ 11 C]CFT BP ND between groups. Results: Unmedicated BPD subjects had significantly lower DAT availability relative to healthy controls in bilateral dorsal caudate. Conclusions: The results of this study support the hypothesis that there are abnormalities in the dopaminergic system in BPD, and suggest that DAT availability may be related to the neuropathology of BPD. Future studies are needed to determine if DAT availability cycles with disease phase.