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Executive functioning in familial bipolar I disorder patients and their unaffected relatives
Author(s) -
Schulze Katja K,
Walshe Muriel,
Stahl Daniel,
Hall Mei Hua,
Kravariti Eugenia,
Morris Robin,
Marshall Nicolette,
McDonald Colm,
Murray Robin M,
Bramon Elvira
Publication year - 2011
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/j.1399-5618.2011.00901.x
Subject(s) - bipolar disorder , endophenotype , psychology , executive functions , first degree relatives , working memory , bipolar i disorder , psychiatry , executive dysfunction , schizophrenia (object oriented programming) , cognition , schizoaffective disorder , clinical psychology , psychosis , family history , mania , medicine , neuropsychology
Schulze KK, Walshe M, Stahl D, Hall MH, Kravariti E, Morris R, Marshall N, McDonald C, Murray RM, Bramon E. Executive functioning in familial bipolar I disorder patients and their unaffected relatives.
Bipolar Disord 2011: 13: 208–216. © 2011 The Authors.
Journal compilation © 2011 John Wiley & Sons A/S. Objective: To compare the executive function of patients with familial bipolar I disorder (BP‐I) with a history of psychotic symptoms to their first‐degree relatives and normal controls. Methods: Three domains of executive function: response inhibition, working memory, and cognitive set shifting were assessed in 44 familial patients with a lifetime diagnosis of BP‐I who had experienced psychotic symptoms, 42 of their unaffected first‐degree relatives, and 47 controls. Results: Bipolar disorder patients and their unaffected relatives had significantly worse scores for response inhibition compared to healthy controls. The groups did not differ in working memory or cognitive set shifting. Conclusions: Impairments in response inhibition are associated with both psychotic bipolar disorder and genetic liability for this illness. Our results indicate that deficits in this specific domain of executive functioning are a promising candidate endophenotype for psychotic bipolar disorder.